Adipose biology Bone marrow adipose tissue (BMAT) biology

Bone marrow adipose tissue (BMAT)
Sexual dimorphism in adipocytes/adipose tissue

The Japan Diabetes Society
Japanese Society of Hematology

Deciphering the Biology and Function of Bone Marrow Adipose Tissue (BMAT)

Although bone marrow adipose tissue (BMAT) accounts for approximately 10% of total body fat in healthy adults and occupies approximately 70% of the bone marrow (BM) volume, its biological roles remain poorly understood. Our research aims to uncover how BMAT regulates hematopoiesis within the BM microenvironment.

Unraveling the Unique Features of Bone Marrow Adipose Tissue (BMAT)

Emerging evidence suggests that BMAT possesses distinct molecular and metabolic properties compared with white and brown adipose tissues, including unique gene expression profiles and insulin responsiveness. We seek to elucidate the developmental and functional basis of these unique features of BMAT.

Sex-Specific Metabolic Responses to Caloric Restriction

Caloric restriction (CR) has garnered attention as a nutritional intervention capable of improving metabolic health and even extending lifespan in animal models. It is noteworthy that metabolic responses to CR vary substantially by age and sex. Our current work focuses on dissecting the sex-dependent metabolic adaptations to CR, with a particular emphasis on adipose tissue biology.