Pathology, Translational Medicine, Immunology

Developing novel diagnostic pathology frameworks by integrating tissue resilience profiling for personalized medicine

The Japanese Society of Pathology
The Japanese Society of Clinical Cytology

My research goal is to establish a holistic diagnostic pathology framework, integrating tissue resilience for personalized medicine and optimal therapeutic strategies. Conventional pathologic diagnosis primarily focuses on characterizing diseases themselves. However, clinical outcomes often vary among patients with the same histological classification, suggesting that additional factors—such as an individual’s intrinsic recovery capacity, or resilience—play a critical role.
Leveraging my multidisciplinary expertise across pathology, translational medicine and immunology, I aim to develop clinically applicable methods to quantify tissue resilience as metrics of patient recovery, and to integrate them into pathological diagnosis. This would provide a holistic diagnostic framework, allowing both precise disease characterization and the evaluation and promotion of patients’ intrinsic recovery potential.

As a SiRIUS Principal Investigator, I aim to:

• Advance personalized medicine by linking tissue resilience with therapeutic response.
• Explore how the dynamics of resilience can inform early intervention and cancer prevention.
• Promote a systemic understanding of human resilience across different organs and tissues.

By combining precise pathological diagnosis with resilience as a patient-centered recovery metric, my goal is to establish a holistic diagnostic framework that supports optimal clinical decision-making, enhances therapeutic effectiveness, and advances personalized medicine.